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BIO4™ Viable Bone Matrix

Specialties:

Fusion/biologics

Description:

BIO4 possesses all four characteristics involved in bone repair and regeneration: osteoconductive, osteoinductive, osteogenic, and angiogenic.[1][2][3] It is an alternative to autograft, which minimizes the potential for harvest site comorbidities.

Features and benefits:

  • Lot tested for the presence of VEGF (vascular endothelial growth factor)
  • Lot tested for ≥70% cell viability post-thaw
  • Contains ≥600,000 cells/cc (endogenous bone forming cells including mesenchymal stem cells)
  • Ready to use out of the package; no decanting is required, and thaws in 15 minutes
  • Differentiated handling compared to competition
  • Non-immunogenic
  • Available in 1, 2.5, 5 and 10cc sizes

 
For more information

  1. ^Data on file at Osiris Therapeutics, Inc.
  2. ^Roberts and Rosenbaum, "Bone grafts, bone substitutes and orthobiologics," Organogenesis (2012)
  3. ^Bourke et al., "Vascular Endothelial Growth Factor (VEGF) in Human Peristeum - Normal Expression and Response to Fracture," Journal of Bone & Joint Surgery, British Volume (2003)
Literature Number: BIBI4-WB-4_18862

Resource center

 

United States/English

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The information presented is intended to demonstrate the breadth of Stryker product offerings. A healthcare professional must always refer to the package insert, product label and/or instructions for use before using any Stryker product. Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Stryker representative if you have questions about the availability of Stryker products in your area.

Stryker or its affiliated entities own, use, or have applied for the following trademarks or service marks: Aero, Berchtold, BIO4, Clarity, CORE, Cranial iD, CranialMap, CranialMask, DirectInject, DuraMatrix, πdrive, ES2, Everest, Excelsior, FlowGate, Gateway, HydroSet, iSuite, iVAS, LITe, Maestro, Malis, MEDPOR, Mesa, MultiGen, Nano, Neuroform EZ, OASYS, SL-10, SDC3, Serengeti, Serrato, SILVERGlide, Sonopet, Spetzler, SpineJack, SpineMap, SpineMask, Stentriever, Streamline, Stryker, Stryker iD, Stryker NAV3i, Switchpoint Infinity, Synchro, Target, Target XL, TransForm, Trevo, Tritanium, Universal Neuro, Venom, Vitoss, VLIFT, Wingspan, Xia, XT-17, XT-27. All other trademarks are trademarks of their respective owners or holders.

The absence of a product, feature, or service name, or logo from this list does not constitute a waiver of Stryker’s trademark or other intellectual property rights concerning that name or logo.

DuraMatrix is a registered trademark of Collagen Matrix, Inc.

BIO4 is manufactured by Osiris Therapeutics, Inc.

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